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Among the unexplained phenomena associated with the galactic barrier was that it could generate an extreme acceleration in psionic ability in some Humans. Gary Mitchell was the most notorious example. (TOS: "Where No Man Has Gone Before")
The non-corporeal lifeform known as Onaya stimulated the creativity of other beings using psionic energy. She also left behind traces of psionic energy in her environment that persisted for a few minutes, which could be detected by tricorders. (DS9: "The Muse")