A prime number is a number with a certain universally recognizable characteristic. A Prime is a natural number that has exactly two distinct natural number divisors: 1 and itself. The first twenty-five prime numbers are:

2, 3, 5, 7, 11, 13, 17, 19, 23, 29, 31, 37, 41, 43, 47, 53, 59, 61, 67, 71, 73, 79, 83, 89, 97.

When captured by unknown aliens in 2366, Captain Jean-Luc Picard signaled the first six prime numbers by pushing the same button in sequence, hoping to prove to his captors that he was intelligent. (TNG: "Allegiance")

Astronomers on Kelemane's planet also signaled prime numbers to the "Sky Ship" in an effort to communicate. (VOY: "Blink of an Eye")

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