Prema II was the inhabited second planet in its star system. The system was located in the Delta Quadrant. A Talaxian mining colony was located on this planet.
In 2372, the colonists agreed to help the USS Voyager in the event of a Kazon attack. (VOY: "Basics, Part I")
After Voyager was captured by the Kazon-Nistrim, two fighters from Prema II assisted in Tom Paris' plan to retake the ship. (VOY: "Basics, Part II")