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A polyalloy was a material used in structures which need to withstand extreme stress. Data's upper spinal support was made from a polyalloy. (TNG: "The Chase")

In 2372, an alien probe composed primarily of duritanium polyalloy was destroyed by the Cardassian ATR-4107. (VOY: "Dreadnought")

The Nausicaan disruptor pistol used polyalloy casing to render the weapon all but invisible to security screeners. (DIS: "Will You Take My Hand?")