Like all other planets in this system, save for Pollux IV, the planet bore no signs of intelligent life, which was statistically unexpected when the planet was examined by the USS Enterprise in 2267. (TOS: "Who Mourns for Adonais?")
Pollux V was featured in the video game Star Trek: 25th Anniversary. Pollux V became the site of the Federation Nikolasi (β) colony established by followers of the Acolytes of the Stars (β) religion. In 2268, the Enterprise was called to the Pollux system when the colonists began to encounter "demons". The demons turned out to be robots created by an automated defense system, taking the form of the worst fear of the intruder. The Enterprise crew discovered members of the native species of the planet, an insectoid race called the Nauians (β). They had remained underground in suspended animation for millennia. After the first contact, Nauians applied for Federation membership.