(written from a Production point of view)
Point Barrow was an Alaskan city mentioned in the first draft script of DS9: "One Little Ship", which likened the idea of being assigned to escort the wives of Cardassian diplomats on inspection tours of the planet Breen to being ordered to guard a weather observation station at Point Barrow.
Point Barrow was also barely visible, marked as the northernmost point of the United States of America on a political map of the North Pacific region. This map was accessed from the USS Enterprise's library computer by the Talosians in 2254. (TOS: "The Cage")