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On stardate 41463.9, the USS Enterprise-D was mapping the cluster. During the mission, the Enterprise was asked by the Federation to visit terraformers on Velara III. Soon after resolving a conflict with microbrain, the lifeform native to Velara III, the Enterprise returned to an unnamed starbase with the surviving terraformers. (TNG: "Home Soil")
While on a date, on a holographic recreation of Mars, with Danara Pel, The Doctor pointed out the Pleiades Cluster as among the many star formations and astronomical highlights seen from Mars. (VOY: "Lifesigns")