A pilgrimage was a journey to a religious location for spiritual significance.

In 2151, Prah Mantoos, a group of his species and a group of Borothan pilgrims ferried by Fraddock made a pilgrimage to the Great Plume of Agosoria and later witnessed the Plume in Enterprise NX-01's mess hall. (ENT: "Cold Front", "Detained")

In 2153, Pri'Nam D'Jamat and his group of Triannon followers took a pilgrimage to the twelfth sphere in the Delphic Expanse, where they encountered Enterprise and eventually took over the vessel. (ENT: "Chosen Realm")

In 2287, Sybok hijacked the USS Enterprise-A to undertake a pilgrimage to Sha Ka Ree which he told his followers would be "the greatest adventure of all time." (Star Trek V: The Final Frontier)

Quark made a pilgrimage to the Great Marketplace on Ferenginar while visiting home in 2372. (DS9: "Body Parts")

In 2376, Dala claimed she undertook a pilgrimage to Narva each spring in honor of the Redeemer of Light. (VOY: "Live Fast and Prosper")

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