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Orion slave girls secreted a highly-potent pheromone that accelerated the metabolisms of males of many species, raising adrenaline production to dangerous levels. It caused aggression and a form of delusion that made them susceptible to suggestion. The pheromone caused headaches in Human females and disrupted the sleep cycle of Denobulan males; Vulcans, however, were immune. The pheromone's effects were cumulative: the longer one was exposed, the more pronounced the results. In 2154, Dr. Phlox of the Enterprise NX-01 theorized that the pheromone acts as a defense mechanism against competition. (ENT: "Bound")
In The Adventures of Captain Proton holoprogram, the character of Queen Arachnia had in her possession a small vial of her pheromones, which she could use to seduce and control others. Kathryn Janeway, as Arachnia in 2375, used these pheromones against the character of Lonzak. (VOY: "Bride of Chaotica!")