Perrin was Ambassador Sarek's last wife and at least the second Human he married. She was with him when he began to experience the effects of Bendii Syndrome while on board the USS Enterprise-D after the signing of a treaty with a species known as the Legarans. She was responsible for nursing him until he finally succumbed to the debilitating effects of his illness in 2368. (TNG: "Sarek")
Before Sarek's death, Captain Jean-Luc Picard visited Vulcan to talk with him about his son Spock's apparent defection or abduction to Romulus. Perrin came aboard the Enterprise-D and met with Picard, who had once taken part in a mind meld with Sarek. Perrin did not get along with Spock. She was upset with him because he didn't bother to say goodbye to his father. She was further upset because Spock had publicly challenged Sarek's arguments during the debate over the Federation-Cardassian War. She was able to inform Picard that Spock was definitely not abducted, that he put his affairs in order before leaving Vulcan. At first she did not want to allow Picard to see Sarek because he was so ill, and she doubted Sarek knew why Spock left. She finally consented to let Picard see him because of the mind meld they had shared.