Payloads was an agency in 2150s Starfleet. This agency had offices at Starfleet Command's Fleet Operations Center, Sol Sector.
In January of 2155, Starfleet officers M. DeMeritt, A. Fredrickson, J. Lewis, B. Lederman, L. Castro, D. Anderson, F. Viramontes, K. Ballard, and R. Deperna were working in this agency. The agency and the officers' names were listed on directory placards. (ENT: "Demons", directories)
Payloads, like many of the other agencies and titles on the directories, was a reference to NASA and ISS terminology, in this case, the "Assembly and Checkout Officer" or "Payloads Officer".