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(covers information from several alternate timelines)
Paranoia was an overwhelming fear of one's environment and/or current situation, often leading to illogical responses to various stimuli, however minor.
When a humanoid is unable to enter into REM sleep for a prolonged period of time, they may suffer from paranoia or hallucinations. This happened to the crew of the USS Enterprise-D when it became trapped in a Tyken's Rift, in 2367. (TNG: "Night Terrors")
In 2369, Ferengi bartender Quark told Constable Odo that he thought he was paranoid, after Odo spotted two Miradorn nodding in his direction. Denying any suggestion that he was involved in illegal activities, Quark theorized that all shapeshifters must be the same, evidenced by the fact nobody had seen one at that point. (DS9: "Vortex")
Later that year, the IKS Toh'Kaht fell under the influence of a set of energy spheres on Saltah'na, causing paranoia and factionism among its crew, a re-enactment of the events that led to the destruction of the Saltah'na species. (DS9: "Dramatis Personae")
The Kesprytt were a species native to the planet Kesprytt III. They were divided into two rivaling nation-states known as the Kes and the Prytt. In 2370, the bigger part of this species (the Kes) applied for associate Federation membership, but this request was denied. Due to the long conflict between the two nations, all Kesprytt had developed a strong sense of paranoia and xenophobia. (TNG: "Attached")
Also in that year, the replicant version of Chief Miles O'Brien described the Paradans as being paranoid due to their obsession with security, though he could understand it after twelve years of civil war. (DS9: "Whispers")
During one of their lunches on the replimat of Deep Space 9, in 2371, Doctor Julian Bashir called Garak paranoid after the Cardassian spy-turned-tailor implied that he would be killed should he leave the station. (DS9: "Second Skin")
Later that year, Garak used the term when referring to Gul Dukat's counter-insurgency program and the unusually large number of interrogative subroutines he had planted in the code. (DS9: "Civil Defense")
Unknown that she and Tom Paris were scanned by the Srivani, B'Elanna Torres thought someone was watching her kissing Paris in a Jefferies tube. She then laughed about herself and thought she went paranoid. (VOY: "Scientific Method")
In 2374 in the alternate timeline known as the "Year of Hell," Lieutenant Tom Paris stated to Commander Chakotay regarding Captain Annorax's belief that time had a personal grudge against him, "That's called paranoia, Chakotay, with a hint of megalomania." (VOY: "Year of Hell, Part II")
At the end of the year, Janeway hoped that she and Tuvok were "just suffering from some good old-fashioned paranoia" regarding their suspicions about Arturis and the USS Dauntless. (VOY: "Hope and Fear")