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A painkiller was a medicine that eased one's pain.

Doctor Beverly Crusher gave Jean-Luc Picard a painkiller when he was experiencing an unknown form of pain when DaiMon Bok returned his previous command starship, the USS Stargazer. (TNG: "The Battle")

In 2372, Doctor Julian Bashir gave Norva a painkiller. However, it had no effect as she was experiencing the final stages of the Teplan blight. (DS9: "The Quickening")

After Jadzia Dax was injured by a Jem'Hadar weapon on Soukara, Worf gave her painkillers, although the anticoagulant from the Dominion weapon meant she needed to take more. (DS9: "Change of Heart")

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