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A painkiller was a medicine that eased one's pain.

Doctor Beverly Crusher gave Jean-Luc Picard a painkiller when he was experiencing an unknown form of pain when DaiMon Bok returned his previous command starship, the USS Stargazer. (TNG: "The Battle")

In 2365, Katherine Pulaski offered Deanna Troi something for the pain she presumed childbirth was causing, but Troi was experiencing no pain. (TNG: "The Child")

In 2372, Doctor Julian Bashir offered Meso'Clan pain medication after the Jem'Hadar's knee joint had been destroyed by a plasma charge. (DS9: "Hippocratic Oath")

Later that year, Bashir gave Norva a painkiller. However, it had no effect as she was experiencing the final stages of the Teplan blight. (DS9: "The Quickening")

After Jadzia Dax was injured by a Jem'Hadar weapon on Soukara in 2374, Worf gave her painkillers, although the anticoagulant from the Dominion weapon meant she needed to take more. (DS9: "Change of Heart")

In 2375, Tom Paris administered pain medication to Samantha Wildman for injuries she had sustained in the crash of the Delta Flyer. (VOY: "Once Upon a Time")

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