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Doctor Julian Bashir administered ovarian resequencing enzymes to Jadzia Dax in 2374 to allow her and her husband Worf to have a child together despite their normally incompatible physiologies. Bashir found that they appeared to have been working well, but Jadzia's untimely death at the hands of a Pah-wraith controlled Dukat precluded the possibility of a child being created. (DS9: "Tears of the Prophets")