A neuropeptide is any of a family of molecules formed by a short chain of amino acids and which plays a role in humanoid brain activity. An increase or decrease in neuropeptide levels may be a cause or symptom of abnormal brain activity.

In 2372, the neuropeptide levels in Tuvok's limbic systems decreased by 15 per cent, after a mind meld with Lon Suder. (VOY: "Meld")

An overabundance of neuropeptides was the scientific explanation offered by Doctor Julian Bashir in 2373 for Captain Benjamin Sisko's Orb shadow hallucinations. These can occur a long time after a direct Bajoran Orb experience. Sisko accepted treatment to restore his neuropeptide levels and make the visions stop. (DS9: "Rapture")

Also in 2373, The Doctor noted that Kathryn Janeway's neuropeptides had risen to an abnormal level during her Nechani endurance ritual. (VOY: "Sacred Ground")

When a Human is made part of a Borg neural link via a neural transceiver, its neuropeptide levels became abnormally high until the connection was severed. Chakotay experienced this in 2373, and The Doctor hypothesized that this increased his telepathic receptivity. (VOY: "Unity")

In 2378, Lieutenant Commander Tuvok required fal-tor-voh, a treatment for a Vulcan degenerative neurological disease, which involves receiving a mind meld. The disease causes the neuropeptide levels in the Vulcan brain to decrease, and affects their logic capabilities. (VOY: "Endgame")

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