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In 2378, Captain Janeway's counterpart from twenty-six years in the future deliberately infected herself with a neurolytic pathogen, and subsequently allowed herself to be assimilated by the Borg Queen, as part of a plot to destroy the Borg's transwarp network. As the pathogen began to take effect, the Queen lost contact with the majority of the Collective, and the shielding protecting the interspatial manifolds supporting the network, which the Queen regulated personally, began to destabilize. This allowed the crew of the USS Voyager to fire a series of transphasic torpedoes, destroying the manifolds and causing the network to collapse. As the pathogen continued to affect the Queen, her cybernetic limbs began to fall off, and the Borg Unicomplex was destroyed. Before she died, the Queen said Sphere 634 could still hear her thoughts and had assimilated the pathogen (Voyager was inside the Sphere).(VOY: "Endgame")