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In 2375, Julian Bashir planned to stimulate the growth of synapses in Sarina Douglas' thalamus. This could be achieved by manipulating neural proteins at the subatomic level. Starfleet's most advanced neurocortical probe wasn't remotely accurate enough and Miles O'Brien considered it impossible to improve, since at smaller resolutions quantum fluctuations weren't controllable. Lauren, Patrick and Jack were able to improve it though by recalibrating the imaging diodes and combine it with a tricorder. (DS9: "Chrysalis")