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(written from a Production point of view)
A deleted scene from ENT: "E²" established the Neubilean fever as a type of fever. In 2154, eight crewmembers aboard a particular version of Enterprise NX-01 from an alternate timeline were suffering from low-grade Neubilean fever. As a result, Doctor Phlox wanted to vaccinate everyone aboard both that ship and the Enterprise from the prime universe.