Sharing common ancestors with Humans, Neanderthals (or Homo neanderthalensis) were a humanoid species on Earth, which became extinct approximately 28,000 years ago. It is assumed that, in contrast to their Human rivals, the extinction of Neanderthals was in part due to their inability to cope with rapidly changing environmental conditions and completion with Humans.
In 1996, Henry Starling said that the crew of the USS Voyager might think of him as "some backwards 20th century Neanderthal that doesn't know what he's got", with regards to his 29th century technology, but he proved otherwise to them. (VOY: "Future's End, Part II")
When Phlox attempted to compare the DNA from a Xindi-Reptilian to that of a Xindi-Primate in early 2153, he noted that the Primate's genetic profile was nearly identical, but not quite the same, as the Reptilians. In noting this difference, Phlox agreed with Jonathan Archer that the best analogy might be in comparing a Human and a Neanderthal, rather than a Human to a chimpanzee. (ENT: "The Xindi")