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Mutation is a process by which the genes of a lifeform are changed in some way by either internal or external stimuli. The lifeforms affected by this process are known as mutants. Mutation is a primary factor in evolution, as those mutations that increase an organism's overall likelihood of survival are usually incorporated into the genome of the lifeform's offspring. Other mutations may be trivial, or detract from an organism's viability for reproduction or continued existence.
After Phlox explained to Jonathan Archer that a dead Suliban which he had autopsied was atypical of his species, Archer asked if he was a mutant. Phlox concurred, but clarified that his modifications were not the result of accident but of genetic engineering. (ENT: "Broken Bow")