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In 2375, Nog suffered severe thermal damage to his femoral motor nerves after being shot in the leg by a Jem'Hadar weapon. Dr. Julian Bashir was unsure if the nerves would be able to stimulate artificial muscle tissue and the leg was ultimately lost. (DS9: "The Siege of AR-558")
In 2376, after apparent dark matter lifeforms had entered William Telfer's body and briefly immobilized him, they activated his motor neurons and allowed him to pass through a force field. (VOY: "Good Shepherd")