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The motor cortex was the regions of the cerebral cortex involved in the planning, control, and execution of voluntary movements and motor skills.

In 2370, Doctor Julian Bashir, who was attempting to help Melora Pazlar acquire the ability to walk, viewed a computer model depicting simulated acetylcholine absorption as a means of creating elevated neural output from the brain's gross motor cortex in effort to increase her muscular tensile strength. (DS9: "Melora")

In 2373, The Doctor's "daughter" Belle hit her head causing severe cranial trauma that compromised her brain stem and motor cortex. (VOY: "Real Life")

After Seven of Nine went into neural shock in 2374, The Doctor told Kes to try and stabilize her motor cortex with a neurosequencer. (VOY: "The Gift")

In 2375, Seven believed her motor cortex and visual processors were malfunctioning, after she had been intoxicated by a single glass of wine. (VOY: "Timeless")

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