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In 2366 Doctor Paul Stubbs compared sentient nanites that were created accidentally by Wesley Crusher to mosquitoes and said, when Commander William T. Riker asked why the nanites would attack the USS Enterprise-D: "Why does a mosquito bite your ear and who cares? The answer is simple. Call an exterminator!" (TNG: "Evolution")
Dr. Beverly Crusher used the metaphor "What if we look at it from a mosquito's point of view... if we sting them in a tender spot, they might stop for a minute to scratch," in reference to forcing the Borg cube that kidnapped Captain Jean-Luc Picard out of warp. (TNG: "The Best of Both Worlds")