The Moselina system was a star system. The USS Enterprise-D was en route to the Moselina system in 2368 when it was diverted to destroy an asteroid on a collision course with Tessen III.

While underway to the Moselina system after dealing with the asteroid, the Enterprise was to host the wedding of Lwaxana Troi and Minister Campio of Kostolain, but the wedding was canceled. (TNG: "Cost of Living")

According to Star Trek: Star Charts ("United Federation of Planets IV") and Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), the Moselina system was located in the Beta Quadrant. The primary was a K-class star.