According to her psychological profile, Mira had a history of psychosomatic illness that consisted of occasional and teenage routine incidents. Mira was highly marked for her extreme flexibility and exceptional pliancy to new learning situations.
In 2269, Lt. Romaine was given her first deep space assignment aboard the USS Enterprise when she was placed in charge of supervising the transfer of equipment to Memory Alpha. While aboard the Enterprise, she became romantically involved with Montgomery Scott.
During the mission, Romaine's mind came under attack by a group of non-corporeal lifeforms called the Zetarians, at which time she fainted. She later had several premonitions, including that of the attack on the Enterprise, the attack on Memory Alpha, and finally one of Scotty's death.
Later, when the Enterprise fired its phasers at the shadowing Zetarians, Mira experienced harsh pain. After reporting to sickbay, Dr. McCoy gave her a standard Steinman analysis. The results showed that physically her readings were identical, however, two of her hyperencephalograms indicated that her brain circuitry patterns had been altered. They were eventually identified as the impulse tracking patterns of the Zetarian cloud shadowing the Enterprise.
According to the Star Trek: The Next Generation novel Takedown Romaine later had a medical facility named after her that was dedicated to helping Starfleet officers who had undergone similar takeovers of their mental faculties by aliens.