Multiple realities(covers information from several alternate timelines)
The Midwest was a region on Earth. Midwestern settlements included Riverside and Portage Creek.
In late 2000, Shannon O'Donnel traveled through the Midwest on her way to Florida. (VOY: "11:59")
In an alternate reality, when Christopher Pike first met James T. Kirk, he described Kirk as "the only genius-level repeat offender in the Midwest". (Star Trek)
According to the early reference work Who's Who in Star Trek, by the latter half of the 21st century the Apache had reclaimed a sizable portion of their lands in the midwest.