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While inside a nucleogenic cloud being in 2371, USS Voyager used a class-4 microprobe to draw the multi-polar charges from the creature while it "sutured" the wound with nucleonic beams. (VOY: "The Cloud")
Later that year, Voyager launched a microprobe into a micro-wormhole to trace its subspace bearing, but the probe became lodged in a gravitational eddy inside. Harry Kim subsequently modified the communication system so the probe could act as a subspace relay station, allowing Voyager to make contact with the Talvath on the other side. The probe was eventually crushed by the wormhole's collapse. (VOY: "Eye of the Needle")