In 2376, at the age of eight, the Borg cube she was aboard was disabled by a pathogen that killed all the adult drones. She and four other young drones were disconnected from the Collective. They captured the Delta Flyer with Chakotay, Tom Paris, Harry Kim, and Neelix on board. The five Borg children demanded USS Voyager's deflector array in exchange for the hostages. The deflector array would have allowed them to contact the Borg, but would have left Voyager unable to go to warp.
Seven of Nine discovered that the Borg had received a distress call from the cube, but had determined the children to be irrelevant and had not dispatched any other ships to reconnect them to the hive mind. After the children realized this, they decided to leave the cube. (VOY: "Collective") After her implants were removed, Mezoti slowly regained her individuality. She was helped by Seven of Nine along with Icheb, Azan, and Rebi. Voyager was unable to contact the Norcadians, but were successful in locating Azan and Rebi's people, the Wysanti, in 2377. The Wysanti agreed to give Mezoti a home with the twins. (VOY: "Imperfection")