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(covers information from several alternate timelines)
Shortly before 2268, Dr. Richard Daystrom developed multitronics – a method of constructing a computer that could think, and of impressing memory engrams upon its circuits. The result was the M-5 computer, developed with Daystrom's own engrams. As Daystrom was near a nervous breakdown at the time, the M-5 was (like its predecessors M-1 through M-4) "not entirely successful". While multitronics showed some promise, it was eventually superseded by isolinear circuitry. (TOS: "The Ultimate Computer")
The Banea punished murderers by forcing them to relive their victim's last moments every fourteen hours; this was done by inserting the memory engrams of the victim into their brain. (VOY: "Ex Post Facto")
The Mari sought out memory engrams that contained the memories of violent thoughts. The Mari then removed those engrams, because having violent thoughts was a crime on their world. This procedure was known as an engramatic purge. (VOY: "Random Thoughts")
In 2375, several of Data's memory engrams were damaged after he was shot by a Son'a weapon on the Ba'ku planet. This caused the activation of his memory loss fail-safe system. Later, on board the USS Enterprise-E, Geordi La Forge replaced them. When Data was reactivated, his first inquiry was pertaining to the missing engrams. (Star Trek: Insurrection)
In 2379 of an alternate timeline, Kes had lost over ninety-nine percent of her memory engrams due to the effect of the morilogium. After being sent back in time a few weeks due to a side-effect of The Doctor's bio-temporal chamber, she had lost over ninety-eight percent of the engrams. After yet another such time-shift, to her ninth birthday, the amount was reported as over ninety-five percent. (VOY: "Before and After")