Mass hysteria was a condition in which a large group of individuals would become mentally instable at the same time.

In 2364, following the then-undiagnosed polywater intoxication of the USS Enterprise-D's crew, Jean-Luc Picard asked Doctor Beverly Crusher whether mass hysteria might explain their behavior. (TNG: "The Naked Now")

In 2367, Ventax II citizens experienced mass hysteria following Ardra's ultimatum. (TNG: "Devil's Due")

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