Marie, Robert and René lived at the Picard family farm near La Barre, France on Earth. Although relations between Jean-Luc and his brother were strained, Marie corresponded with Jean-Luc to keep him abreast of family matters. However, she and Jean-Luc did not actually meet until he returned home to La Barre for a brief visit in 2367. (TNG: "Family")
In the short story Eleven Hours Out published in Tales of the Dominion War, Marie's niece, Amarante Lebel, graduates from Starfleet Academy during the Dominion War, and becomes friends with Jean-Luc Picard, her uncle-by-marriage.