Until at least 2270, the Federation Starfleet had a policy of mandatory retirement set (for Humans) at age 75.
When, in 2270, Commodore Robert April proved that he was still very much capable of commanding a starship at 75, Starfleet reviewed his appeal to have his retirement delayed. (TAS: "The Counter-Clock Incident") The policy was apparently rescinded by the time of the launch of the USS Enterprise-D, as Leonard McCoy was still a Starfleet admiral at age 137. (TNG: "Encounter at Farpoint")
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