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The Malurian system was a star system with four inhabited planets. It contained the Malurians, a warp-capable humanoid species. In the last census before its destruction, four billion people were counted in the system. (ENT: "Civilization"; TOS: "The Changeling")
In 2267, Dr. Manway sent a routine report. A week later, a distress call was sent from this system by the Malurians. The closest starship to this system, the USS Enterprise, responded to the call. It was determined, by the Enterprise, that the Malurian civilization as well as Dr. Manway's team had been destroyed by the probe Nomad, leaving the system lifeless. (TOS: "The Changeling")