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The makara herb is a native plant of Bajor, a herb known for its medicinal value. It is typically used in Bajoran women to increase their progesterone during pregnancy. It is also known to act as a counter agent to various sedatives, including merfadon.
Doctor Julian Bashir prescribed makara herbs for Major Kira Nerys during her pregnancy in 2372 and 2373, to help with swollen ankles while she was carrying Miles and Keiko O'Brien's baby. She likened the taste to "something that crawled out of Quark's ear." (DS9: "Looking for par'Mach in All the Wrong Places", "The Darkness and the Light")
In 2373, Furel and Lupaza brought Kira fresh makara herbs, picked the previous night on Bajor. Kira's use of makara herbs helped her to resist the merfadon given to her by Silaran Prin. (DS9: "The Darkness and the Light")