Macaroni and cheese was a popular Earth recipe, composed of a pasta, called macaroni, combined with a cheese-based roux.
Macaroni and cheese was among several dishes that Tarquin served for Human Starfleet Ensign Hoshi Sato, shortly after she arrived on his planet. (ENT: "Exile")
In 2024, Benjamin Sisko got a plate of macaroni and cheese along with a slice of bread for Julian Bashir while they were in the Sanctuary District. (DS9: "Past Tense, Part I")
This recipe was also attempted by Neelix. He used an alien substance called brill cheese, made from schplict (grakel milk), that released a dangerous microbe into the life support systems, infecting a bio-neural gel pack with bacteria. (VOY: "Learning Curve")