The MS I Colony was a Federation colony located in the MS system. This colony was located in the same sector as Ohniaka III and the New Berlin Colony.

In 2369, the colony was attacked by the rogue Borg led by Lore, but the attack was soon stopped when the USS Enterprise-D arrived at the scene. (TNG: "Descent")

This colony was only mentioned in dialogue.
According to Star Trek: Star Charts ("United Federation of Planets I"), in 2378, the MS 1 Colony was listed as a Federation member.