The Lysian system was an inhabited star system. The planet Lysia was the homeworld of the Lysians, a warp-capable species, and the capital of their Lysian Alliance. This system was protected by the Lysian Central Command, which was equipped with sentry pods.

In 2368, the Federation starship USS Enterprise-D entered the system while the crew was operating with their memories wiped and under forged orders created by a Satarran agent. (TNG: "Conundrum")

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