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The Lysians were a race that, as of 2368, had been at war with the Satarrans for decades. They were not as technologically advanced as the Federation, but did have starships and starbases.

In 2368, the Satarrans attempted to use the USS Enterprise-D to launch a devastating attack against the Lysian Central Command. They used their memory wipe weapon on the crew, placed an operative known as Kieran MacDuff in the first officer position, and planted false orders from Starfleet Command which stated that the Enterprise was to destroy the Lysian headquarters. Although the crew was unable to restore their full memories by the time they were to attack the Lysian headquarters, Captain Jean-Luc Picard realized that the Lysians posed no threat to the Galaxy-class starship or to the Federation at large, and that the orders must have been falsified. MacDuff's true nature was then revealed, and the Enterprise stood down. (TNG: "Conundrum")

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