Once he went on a cycling trip with the Bloom sisters and broke his leg on the trip; he later married both of the sisters. He was still married to one of them in 2367. Picard described Louis as a "rotten swimmer".
Louis spent a period of time in the field of hydroponics. He left, jokingly calling it "dull." Louis then worked on the New Atlantis Project extensively. In 2367, he became one of 200 supervisors on the project.
When he reunited with Picard in 2367, Louis encouraged him to consider leading the project, given his interest. He even arranged a meeting with government officials for him, but ultimately Picard cancelled the meeting and declined the offer. (TNG: "Family")