Once he went on a cycling trip with the Bloom sisters and broke his leg on the trip; he later married both of the sisters. He was still married to one of them in 2367. Picard described Louis as a "desperately poor swimmer".
In 2367, Louis was the supervisor of the New Atlantis Project. He wanted Picard to take lead of the project and even arranged a meeting with government officials for him, but ultimately Picard cancelled the meeting and declined the offer. (TNG: "Family")