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A lobotomy was a neurosurgical procedure which consisted of cutting away most of the connections to and from the prefrontal cortex.

Among Vulcans, repressed memories caused a physical reaction within the brain which in extreme cases could lead to the mind of the patient literally lobotomizing itself. (citation needededit)

In 2374, Tom Paris compared the Mari's plans to remove violent thoughts from B'Elanna Torres's brain to a lobotomy. (VOY: "Random Thoughts")

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