The Kepla sector was a region of space in the United Federation of Planets, near the Cardassian border.

In 2373, Dominion forces swept through this sector on the first day of the Dominion War, trapping the USS Valiant in enemy territory. (DS9: "Valiant")

This sector was only mentioned in dialogue.
The Star Trek Encyclopedia (4th ed., vol. 1, p. 413) located this sector in the Alpha Quadrant.
According to Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), there was a star system named Kepla, which this sector might possibly be named after,, in the Alpha Quadrant. This was a binary system with a pair of K-class stars.

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