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In 2366, nanites threatened the USS Enterprise-D with destruction of its main computer core during an experiment in the Kavis Alpha sector. After conflict with the crew of the Enterprise, and particularly the experiment's lead scientist Paul Stubbs, the nanites were relocated to Kavis Alpha IV, which Stubbs' influence had helped designate as their new home. The nanites left the Enterprise and began creating their own civilization on this planet. (TNG: "Evolution")