After Commander Chakotay crash landed with shuttlecraft on a planet in the Delta Quadrant in 2374, he was brainwashed by the Vori to fight in their defense contingent. He met Karya when he went into the Larhana settlement, where she lived with her paternal grandfather Penno, and she greeted him with a flower garland.
Karya helped Chakotay recover from his wounds and built a relationship with him. She looked upon him as a great warrior and asked him to take a letter to her brother, Daryo. After the Kradin had captured her village, Karya was sent to an extermination facility when she tried to save her grandfather from the same fate.
Chakotay, who joined the Vori Defense Contingent after this experience, was later found by Tuvok. Tuvok brought him back to the Larhana settlement to prove the situation. At the settlement, Chakotay was again greeted by Karya who did not recognize Chakotay. (VOY: "Nemesis")