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The Kalandan homeworld was a formerly inhabited planet, and was the homeworld of the extinct Kalandans.

A few thousand years before 2268, in building an outpost, the builders inadvertently created a deadly organism. The advanced force on this outpost was destroyed by this organism. Doctor Leonard McCoy theorized that a supply ship arrived at the outpost, the crew became infected, and this infection spread through Kalandan territory, all the way back to the homeworld where it killed the last survivors. (TOS: "That Which Survives")

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