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In 2267, an examination by Doctor McCoy found advanced arthritis in Captain Kirk's shoulder after Kirk complained of shoulder pain. The arthritis was a byproduct of the accelerated aging that Kirk and several other members of the USS Enterprise crew were experiencing. (TOS: "The Deadly Years")
In another case of hyperaccelerated aging, Doctor Pulaski experienced acute arthritic inflammation after being afflicted by aggressive antibodies on the Darwin Genetic Research Station in 2365. (TNG: "Unnatural Selection")
When The Doctor asked Lewis Zimmerman what the initial symptoms of his terminal illness were in 2376, Zimmerman sarcastically told him "radical hair loss", before finally giving The Doctor his true symptoms of fatigue, nausea, and joint inflammation. (VOY: "Life Line")