Doctor Lucas was essentially the counterpart to Doctor Phlox; Lucas was assigned to the capital city of Denobula while Phlox went to Starfleet Command on Earth. The two maintained a long-distance friendship through the occasional subspace letter.
In September of 2151, Lucas mailed Phlox to tell him of his stress during the violent Denobulan mating season. Phlox reciprocated with a story about his new posting on Enterprise NX-01, specifically the outbreak of a plague on Valakis. (ENT: "Dear Doctor")
After the Xindi attacked Earth in March of 2153, Doctor Lucas was recalled to his home planet to help deal with the devastation. Though he sent a letter to Phlox telling him of this, Phlox was unable to respond because of Enterprise's busy involvement in a search for the Xindi weapon. Phlox finally responded in January of 2154, as he caught up on his correspondence while the rest of the crew spent four days in comas. (ENT: "Doctor's Orders")
Later that year, Doctor Lucas was assigned as senior medical director of Cold Station 12, a Medical Exchange facility that housed dangerous pathogens in a secure environment. In May of 2154, the facility was attacked by Doctor Arik Soong and his Augments, seeking access to Augment embryos on the station. Lucas refused to give Soong the access codes, even when Soong killed one of the C12 staff with Symbalene blood burn. Lucas remained defiant until Malik threatened to kill Phlox, who had arrived on station as part of a rescue team. (ENT: "Cold Station 12")