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Istanbul was an ancient Earth city located in Eurasia. In early history, it was known as Constantinople.

In the 13th century, one Crusade resulted in the Sack of Constantinople. (TOS: "The Squire of Gothos", DS9: "Q-Less", VOY: "The Killing Game")

In summer 1334, Constantinople was affected by the Bubonic plague while Flint was in the city. (TOS: "Requiem for Methuselah")

During the 19th and 20th centuries, the city was the destination of the Orient Express. (TNG: "Emergence")

In the Julian Bashir, Secret Agent holoprogram set in the 1960s, Istanbul sent several messages to an island in the South Pacific, that were intercepted by the Americans. (DS9: "Change of Heart")

The USS Constantinople was named after the historic name for this city, and the Star Trek Encyclopedia (3rd ed., p. 85) actually assigns it to the Istanbul class.

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