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Isabel Howard was the wife of Paul Howard, the mother of Beverly Howard (later Crusher) and the maternal grandmother of Wesley Crusher. Isabel and her daughter Beverly were the first two Howard women who did not have green eyes. (TNG: "Conundrum", "Sub Rosa")
Isabel died when Beverly was very young, leaving Beverly's grandmother, Felisa Howard, to care for her. Beverly remembered her mother well, including her face, her scent, and the fact that she loved her very much. (TNG: "Sub Rosa")