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Irillium is an element which may occur as an impurity in ryetalyn. The presence of irillium in ryetalyn renders it pharmacologically inert, and useless as a treatment for Rigelian fever. (TOS: "Requiem for Methuselah")

According to the Star Fleet Medical Reference Manual, (p. 18) irillium, symbol Im, had the atomic weight 305 and atomic number 116. It was first discovered by Humans in the asteroid belt in 2029.

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