Iota Geminorium IV was the uninhabited fourth planet in its star system. This was the homeworld of the tribble. Reptiles were the natural predators of tribbles on this world, and were known to keep the tribble population in check, which when removed to other environments bred uncontrollably. This planet was located within the Klingon sphere of influence.
In 2369, a chart illustrating various creatures, including tribbles, from around the known galaxy was displayed in a classroom aboard Deep Space 9. (TOS: "The Trouble with Tribbles"; DS9: "The Nagus", okudagram; ENT: "The Breach")
In order to fulfill their self-given task to hunt the tribble species to extinction, a Klingon armada obliterated the Tribbles' homeworld, and by the late 23rd century, the species was entirely eradicated. (DS9: "Trials and Tribble-ations")